The Laboratory of biological electron microscopy and structural biology

(dr. fei sun’s lab)

 
 
 

The Laboratory of Biological Electron Microscopy and Structural Biology(LBEMSB) is an individual research group with the principal investigator, Dr. Fei Sun. It belongs to the National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences (CAS). Besides, Dr. Sun also takes the chief responsibility of the Center for Biological Imaging (CBI), Core Facility for Protein Sciences, CAS, which is well equipped. Our research group is one of the major users of CBI.

Our research will combine X-ray crystallography and cryo-electron microscopy approaches as well as other biophysical and biochemical tools to study the molecular architecture of biological systems from nano-scale to meso-scale. In the next five years, we will focus on (i) Molecular mechanism of mitochondrial and bio-membrane dynamics, (ii) Structure and function of supra macromolecular complexes, and (iii) Methodology development on the biological imaging.

 

Structural Insights into the Life!

Recent News

The recent outbreak of COVID-19 caused by SARS-CoV-2 infection has posed a serious threat to global public health. In collaboration with Fudan University and other research groups, we solved the crystal structure of six-helical bundle (6-HB) core of the HR1 and HR2 domains in the SARS-CoV-2 S protein S2 subunit, and developed a pan-coronavirus fusion inhibitor of EK1C4, which is highly effective against infections of SARS-CoV-2 and other human coronavirus. This work was published as cover story in Cell Research in April 2020.

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