The Laboratory of biological electron microscopy and structural biology

(dr. fei sun’s lab)

 
 
 

The Laboratory of Biological Electron Microscopy and Structural Biology(LBEMSB) is an individual research group with the principal investigator, Dr. Fei Sun. It belongs to the National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences (CAS). Besides, Dr. Sun also takes the chief responsibility of the Center for Biological Imaging (CBI), Core Facility for Protein Sciences, CAS, which is well equipped. Our research group is one of the major users of CBI.

Our research will combine X-ray crystallography and cryo-electron microscopy approaches as well as other biophysical and biochemical tools to study the molecular architecture of biological systems from nano-scale to meso-scale. In the next five years, we will focus on (i) Molecular mechanism of mitochondrial and bio-membrane dynamics, (ii) Structure and function of supra macromolecular complexes, and (iii) Methodology development on the biological imaging.

 

Structural Insights into the Life!

Recent News

In collaboration with  Prof. Jungui Dai from Chinese Academy of Medical Science and Peking Union Medical College, we discovered a novel aromatic prenyltransferase AtaPT that exhibits extraordinary promiscuity for its substrates and products. Our subsequent systematic biochemical and structural work revealed the molecular mechanism of its enzymatic promiscuity. This work shed new light on our knowledge of enzymology and has been published by Nature Chemical Biology recently.

HOME     RESEARCH     PUBLICATIONS     MEMBERS     ALBUM     SOFTWARE     CONTACT     LINKS