The Laboratory of biological electron microscopy and structural biology

(dr. fei sun’s lab)


The Laboratory of Biological Electron Microscopy and Structural Biology(LBEMSB) is an individual research group with the principal investigator, Dr. Fei Sun. It belongs to the National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences (CAS). Besides, Dr. Sun also takes the chief responsibility of the Center for Biological Imaging (CBI), Core Facility for Protein Sciences, CAS, which is well equipped. Our research group is one of the major users of CBI.

Our research will combine X-ray crystallography and cryo-electron microscopy approaches as well as other biophysical and biochemical tools to study the molecular architecture of biological systems from nano-scale to meso-scale. In the next five years, we will focus on (i) Molecular mechanism of mitochondrial and bio-membrane dynamics, (ii) Structure and function of supra macromolecular complexes, and (iii) Methodology development on the biological imaging.


Structural Insights into the Life!

Recent News

In collaboration with Dr. Xiaoling Xu’s group in Hangzhou Normal University, we utilized cryoEM approach to determine the first high-resolution structures of alternative complex III from Roseiflexus castenholzii at both oxidized and reduced states and proposed a novel coupling mechanism between the electron-transfer and proton-translocation. This work was published recently in Science Advances in July 2020.