The Laboratory of biological electron microscopy and structural biology

(dr. fei sun’s lab)

 
 
 

The Laboratory of Biological Electron Microscopy and Structural Biology(LBEMSB) is an individual research group with the principal investigator, Dr. Fei Sun. It belongs to the National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences (CAS). Besides, Dr. Sun also takes the chief responsibility of the Center for Biological Imaging (CBI), Core Facility for Protein Sciences, CAS, which is well equipped. Our research group is one of the major users of CBI.

Our research will combine X-ray crystallography and cryo-electron microscopy approaches as well as other biophysical and biochemical tools to study the molecular architecture of biological systems from nano-scale to meso-scale. In the next five years, we will focus on (i) Molecular mechanism of mitochondrial and bio-membrane dynamics, (ii) Structure and function of supra macromolecular complexes, and (iii) Methodology development on the biological imaging.

 

Structural Insights into the Life!

Recent News

In January 2020, in collaboration with the Max Planck institute, we solved the 3.3 Å resolution structure of respiratory chain complex III from Aquifex aeolicus in both natural state and inhibited state. It’s the first high-resolution three-dimensional structure of respiratory chain complex III from thermophilic species, which reveals the structural basis of complex III to remain stable in extreme environment. This work was published in Angewandte Chemie.

HOME     RESEARCH     PUBLICATIONS     MEMBERS     ALBUM     SOFTWARE     CONTACT     LINKS