The Laboratory of biological electron microscopy and structural biology

(dr. fei sun’s lab)


Year 2020

  1. 1.Huang X.#, Zhang L.#, Wen Z., Chen H., Li S., Ji G., Yin C.C. and Sun F.* (2020) Amorphous nickel titanium alloy film: a new choice for cryo electron microscopy sample preparation. Progress in Biophysics and Molecular Biology. doi: 10.1016/j.pbiomolbio.2020.07.009 [Epub ahead of print]

  2. 2.Lu J.#, Chan C.#, Yu L.#, Fan J.*, Sun F.* and Zhai Y.* (2020) Molecular mechanism of mitochondrial phosphatidate transfer by Ups1. Communications Biology, 3: 468. doi: 10.1038/s42003-020-01121-x

  3. 3.Wu B.* and Sun F.* (2020) Editorial overview: New insights into membrane protein machineries from technology revolution. Current Opinion in Structural Biology. doi: 10.1016/

  4. 4.Shi Y.#, Xin Y.#, Wang C.#, Blankenship R.E., Sun F.* and Xu XL.* (2020) Cryo-EM structure of the air-oxidized and dithionite-reduced photosynthetic alternative complex III from Roseiflexus castenholzii. Science Advances, 6 (31): eaba2739. doi: 10.1126/sciadv.aba2739.

  5. 5.Zhang W., Zhang S., Yan P., Ren J., Song M., Li J., Lei J., Pan H., Wang S., Ma X., Ma S., Li H., Sun F., Wan H., Li W., Chan P., Zhou Q, Liu GH.*, Tang F.* and Qu J.* (2020) A single-cell transcriptomic landscape of primate arterial aging. Nature Communications 11(1): 2202. doi: 10.1038/s41467-020-15997-0.

  6. 6.Zhu G.#, Zhu C.#, Zhu Y.* and Sun F.* (2020) Minireview of progress in the structural study of SARS-CoV-2 proteins. Current Research in Microbial Sciences, doi: 10.1016/j.crmicr.2020.06.003.

  7. 7.Zeng H., Zhu G., Zhang S., Li X., Martin J., Morgner N., Sun F. Peng G., Xie H* and Michel H.* (2020) Isolated heme A synthase from Aquifex aeolicus is a trimer. mBio 11(3): e02615-19. doi: 10.1128/mBio02615-19.

  8. 8.Xia S., Liu M., Wang C., Xu W., Lan Q., Feng S., Qi F., Bao L., Du L., Liu S., Qin C., Sun F.&, Shi Z.&, Zhu Y.*&, Jiang S.*&, and Lu L.*& (2020) Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. Cell Research, 30 (4): 343-355. doi: 10.1038/s41422-020-0305-x. (&: co-senior authors).

  9. 9.Zhang D., Zhang Y., Ma J., Zhu C., Niu T., Chen W., Pang X., Zhai Y., and Sun F.* (2020) Cryo-EM structures of S-OPA1 reveal its interactions with membrane and changes upon nucleotide binding. eLife 9: e50294. doi: 10.7554/eLife.50294

  10. 10.Qiao A., Han S., Li X., Li Z., Zhao P., Dai A., Chang R., Tai L., Tan Q., Chu X., Ma L., Thorsen T.S., Reedtz-Runge S., Yang D., Wang M., Sexton P.M., Wootten D., Sun F.*, Zhao Q.*, and Wu B.* (2020) Structural basis of Gs and Gi recognition by the human glucagon receptor. Science, 367: 1346-1352. doi: 10.1126/science.aaz5346.

  11. 11.Leng F., Yin H., Qin S., Zhang K., Guan Y., Fang R., Wang H., Li G., Jiang Z., Sun F., Wang D.C.* and Xie C.* (2020) NLRP6 self-assembles into a linear molecular platform following LPS binding and ATP stimulation. Scientific Reports, 10: 198. doi: 10.1038/s41598-019-57043-0.

  12. 12.Zhu G., Zeng H., Zhang S., Juli J., Pang X., Hoffmann J., Zhang Y., Morgner N., Zhu Y.*, Peng G.*, Michel H.* and Sun F.* (2020) A 3.3 A-resolution structure of hyperthermophilic respiratory complex III reveals the mechanism of its thermal stability. Angew Chem Int Ed Engl. 59 (1): 343-351. doi: 10.1002/anie.201911554.

Year 2019

  1. 13.Ren Z., Zhang Y., Zhang Y., He Y., Du P., Wang Z., Sun F.* and Ren H.* (2019) Cryo-EM structure of actin filaments from Zea mays pollen. Plant Cell. pii: tpc.00973.2018. doi: 10.1105/tpc.18.00973. [Epub ahead of print]

  2. 14.Shen W., Ma L., Zhang X., Li X., Zhao Y., Jing Y., Feng Y., Tan X., Sun F. and Lin J.* (2019) Three-dimensional reconstruction of Picea wilsonii Mast. pollen grains using automated electron microscopy. Sci China Life. doi: 10.1007/s11427-019-9820-4. [Epub ahead of print]

  3. 15.Qu J., Cao S., Wei Q., Zhang H., Wang R., Kang W., Ma T., Zhang L., Liu T., Wing-Ngor Au.S., Sun F., Xia J.* (2019) Synthetic multienzyme complexes, catalytic nanomachineries for cascade biosynthesis in vivo. ACS Nano., 13(9): 9895-9906. doi: 10.1021/acsnano.9b03631.

  4. 16.Park SY., Yang JS., Li Z., Deng P., Zhu X., Yong D., Ericsson M., Andringa RLH., Minnaard AJ., Zhu C., Sun F. Moody DB., Morris AJ., Fan J., Hsu VW.* (2019) Nature Communications. 10(1):3409. doi: 10.1038/s41467-019-11324-4.

  5. 17.Chan C. Pang X., Zhang Y., Niu T., Yang S., Zhao D., Li J., Lu L., Hsu, V.W., Zhou J.*, Sun F.* and Fan J.* (2019), ACAP1 assembles into an unusual protein lattice for membrane deformation through multiple stages. PLOS Computational Biology,15 (7): e1007081. doi: 10.1371/journal.pcbi.1007081.

  6. 18.Zhai Y.*, Zhang D., Yu L., Sun Fang and Sun F.* (2019), SmartBac, a new baculovirus system for large protein complex production. Journal of Structural Biology:X, 100003. doi: 10.1016/j.yjsbx.2019.100003.

  7. 19.Ma J., Zhai Y., Chen M., Zhang K., Chen Q., Pang X.*, and Sun F.* (2019), New interfaces on MiD51 for Drp1 recruitment and regulation. PLoS One 14, e0211459.

  8. 20.Liu X,, Guo X., Niu L., Li X., Sun F., Hu J., Wang X.* and Shen K.* (2019), Altastin-1 regulates morphology and function of endoplasmic reticulum in dendrites. Nature communications, 10 : 568. doi: 10.1038/s41467-019-08478-6.

  9. 21.Zhang J., Wang Z., Chen Y., Han R., Liu Z., Sun F. and Zhang F.* (2019), PIXER: an automated particle-selection method based on segmentation using a deep neural network. BMC Bioinformatics, 20(1): 41. doi: 10.1186/s12859-019-2614-y.

  10. 22.Han R., Wan X., Li L., Lawrence A., Yang P., Li Y., Wang S., Sun F. Liu Z, Gao X. and Zhang F.* (2019), AuTom-dualx: a toolkit for fully automatic fiducial marker-based alignment of dual-axis tilt series with simultaneous reconstruction. Bioinformatics, 35(2): 319-328. doi: 10.1093/bioinformatics/bty620.

Year 2018

  1. 23.Li X., Zhang S., Zhang J. and Sun F.* (2018), In situ protein micro-crystal fabrication by cryo-FIB for electron diffraction. Biophysics Reports, 4(6): 339-347. doi: 10.1007/s41048-018-0075-x.

  2. 24.Zhang XC*, Yang H, Liu Z and Sun F. (2018), Thermodynamics of voltage-gated ion channels. Biophysics Reports, 4(6): 300-319. doi: 10.1007/s41048-018-0074-y.

  3. 25.Gong H., LI L., Xu A., Tang Y., Ji W., Gao R., Wang S., Yu L., Tian C., Li J., Yen H.Y., Lam S.M., Shui G., Yang X., Sun Y., Li X., Jia M., Yang C., Jiang B., Lou Z., Robinson C., Wong L.L., Guddat L.W., Sun F.*, Wang Q.* and Rao Z.* (2018), A electron transfer path connects subunits of a mycobacterial respiratory supercomplex. Science 362(6418), pii: eaat8923. doi: 10.1126/science.aat8923.

  4. 26.Sun F.* (2018) Orienting the future of bio-macromolecular electron microscopy. Chinese Physics B, 27 (6) : 060503. doi: 10.1088/1674-1056/27/6/06360. [Review-CPB-Orienting the future of bio-macromolecular electron microscopy.pdf]

  5. 27.Xin Y., Shi Y., Niu T., Wang Q., Niu W., Huang X., Ding W., Yang L., Blankenship R. E., Xu X.* and Sun F.*  (2018) Cryo-EM structure of the RC-LH core complex from an early branching photosynthetic prokaryote. Nature communications, 9 : 1568. doi: 10.1038/s41467-018-03881-x.

  6. 28.Luo S., Xie T., Liu Z., Sun F. and Wang G.* (2018), The development of CotA mediator cocktail system for dyes decolorization. Journal of Applied Microbiology, 124 (5): 1164-1174. doi: 10.1111/jam.13721.

  7. 29.Wang Z., Chen Y., Zhang J., Li L., Wan X., Liu Z., Sun F. and Zhang F.* (2018) ICON-MIC: Implementing a CPU/MIC collaboration parallel framework for ICON on Tianhe-2 supercomputer. Journal of Computational Biology, 25 (3): 270-281. doi: 10.1089/cmb.2017.0151.

  8. 30.Li S., Ji G.*, Shi Y., Klausen L.H., Niu T., Wang S., Huang X., Ding W., Zhang X., Dong M., Xu W., and Sun F.* (2018), High-vacuum optical platform for cryo-CLEM(HOPE): a new solution for non-integrated multiscale correlative light and electron microscopy. Journal of Structural Biology, 201(1): 63-75. doi: 10.1016/j.jsb.2017.11.002.

Year 2017

  1. 31.Chen Y., Wang Z., Li L., Wan X., Sun F. and Zhang F.* (2017) A fully automatic geometric parameters determining method for electron tomography. ISBRA (International Symposium on Bioinformatics Research and Applications) 2017. 385-389. doi: 10.1007/978-3-319-59575-7 39

  2. 32.Shi Y., Wang L., Zhang J., Zhai Y., and Sun F.* (2017), Determining the target protein localization in 3D using the combination of FIB-SEM and APEX2. Biophysics Reports, 3: 92-99. doi: 10.1007/s41048-017-0043-x

  3. 33.Li X., Ji G.*, Chen X., Ding W., Sun L., Xu W., Han H., and  Sun F.* (2017), Large scale three-dimensional reconstruction of an entire Caenorhabditis elegans larva using AutoCUTS-SEM. Journal of Structural Biology, 200(2): 87-96. doi: 10.1016/j.jsb.2017.09.010.

  4. 34.Han R., Wan X., Wang Z., Hao Y., Zhang J., Chen Y., Gao X., Liu Z., Ren F., Sun F.*, and Zhang F.* (2017), AuTom: a novel automatic platform for electron tomography reconstruction. Journal of Structural Biology, 199(3): 196-208. doi: 10.1016/j.jsb.2017.07.008.

  5. 35.Wang S., Li S., Ji G., Huang X. and Sun F.* (2017), Using integrated correlative cryo-light and electron microscopy to directly observe syntaphilin-immobilized neuronal mitochondria in situ. Biophysics Reports, 3: 8-16. doi: 10.1007/s41048-017-0035-x

  6. 36.Wang Z., Chen Y., Zhang J., Li L., Wan X., Liu Z., Sun F., Zhang F.* (2017), ICON-MIC: Implementing a GPU/MIC collaboration parallel framework for ICON on Tianhe-2 supercomputer. Journal of Computation Biology. doi: 10.1089/cmb.2017.0151. [Epub ahead of print]

  7. 37.Chen Y., Wang Z., Zhang J., Li L., Wan X., Sun F.*, and Zhang F.* (2017), Accelerating electron tomography reconstruction algorithm ICON with GPU. Biophysics Reports, 3: 36-42. doi: 10.1007/s41048-017-0041-z

  8. 38.Lu G., Xu Y., Zhang K., Xiong Y., Li H., Cui L., Wang X., Lou J., Zhai Y.*, Sun F.* and Zhang X.C.* (2017), Crystal structure of E. coli apolipoprotein N-acyltransferase. Nature Communications, 8:15948. doi: 10.1038/ncomms15948. 

  9. 39.Zhou Y., Lou H., Liu Z., Yang M., Pang X., Sun F. and Wang G.* (2017), Structural insight into the specific DNA template binding to DnaG primase in Bacteria. Scientific Report, 7(1): 659. doi: 10.1038/s41598-017-00767-8.

  10. 40.Chan K.C., Lu L., Sun F., Fan J. (2017), Molecular details of the PH domain of ACAP1BAR-PH protein binding to PIP-containing membrane. J Phys Chem B,121(15): 3586-3596. doi:10.1021/acs.jpcb.6b09563. [Epub ahead of print]

  11. 41.Chen R., Gao B., Liu, X., Ruan F., Zhang Y., Lou J., Feng K., Wunsch C., Li S.M., Dai J.* and Sun F.* (2017), Molecular insights into the enzyme promiscuity of an aromatic prenyltransferase. Nature Chemical Biology (Advanced online at Dec. 19, 2016), 13(2): 226-234. doi: 10.1038/nchembio.2263. [This research has been recommended In F1000Prime]


Year 2016

  1. 42.Wei R., Wang X., Zhang Y., Mukherjee S., Zhang L., Chen Q., Huang X., Jing S., Liu C., Li S., Wang G., Xu Y., Zhu S., Williams A., Sun F.* and Yin C.C.* (2016), Structural insights into Ca2+ -activated long-range allosteric channel gating of RyR1. Cell Research 26: 977-994 (Cover story). doi: 10.1038/cr.2016.99

  1. 43.Wang S., Zhai Y., Pang X., Niu T., Ding Y.H., Dong, M.Q., Hsu W.V. Sun Z.* and Sun F.* (2016), Structural characterization of coatomer in its cytosolic state. Protein Cell 7(8): 586-600. doi: 10.1007/s13238-016-0296-z. [This research has been recommended In F1000Prime, 12 Dec 2016; DOI: 10.3410/f.726587512.793525970.]

  2. 44.Chen Y., Zhang Y., Zhang K.*, Deng Y., Zhang F.* and Sun F.* (2016), FIRT: filtered iterative reconstruction technique with information restoration. Journal of Structural Biology 195(1) : 49-61. doi: 10.1016/j.jsb.2016.04.015.

  3. 45.Deng Y., Chen Y., Zhang Y., Wang S., Zhang F.* and Sun F.* (2016), ICON: 3D reconstruction with ‘missing-information’ restoration in biological electron tomography. Journal of Structural Biology 195(1) : 100-112. doi: 10.1016/j.jsb.2016.04.004.

  4. 46.Zhang J., Ji G., Huang X., Xu W.* and Sun F.* (2016), An improved cryo-FIB method for fabrication of frozen hydrated lamella. Journal of Structural Biology 194(2): 218-223. doi: 10.1016/j.jsb.2016.02.013.

  5. 47.Li W., Ding W., Ji G., Zhang J. and Sun F.* (2016), Three-dimensional visualization of arsenic stimulated mouse liver sinusoidal by FIB-SEM approach. Protein Cell 7(3) : 227-232. doi: 1007/s13238-016-0246-9.

  6. 48.Shan H., Wang Z., Zhang F., Xiong Y., Yin C.C.* and Sun F.* (2016), A local-optimization refinement algorithm in single particle analysis for macromolecular complex with multiple rigid modules. Protein Cell 7(1): 46-62. doi:10.1007/s13238-015-0229-2.

  7. 49.Mao G., Zhao Y., Kang X., Li Z., Zhang Y., Wang X., Sun F., Sankaran, K., and Zhang, X.C. (2016), Crystal structure of E. coli lipoprotein diacylglyceryl transferase. Nature communications 7, 10198.

Year 2015

  1. 50.Cui Y., Zhao S., Wang J., Gao B., Fan Q., Sun F. and Zhou B. (2015), A novel mitochondrial carrier protein Mme1 acts as a yeast mitochondrial magnesium exporter. Biochim Biophys Acta. 1854(3): 724-32. doi:10.1016/j.bbamcr.2014.12.029.

  2. 51.Ma D.K., Li Z., Lu A.Y., Sun F., Chen S., Rothe M., Menzel R., Sun F. and Horvitz HR.* (2015), Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids. Cell, 161(5) : 1152-63. doi: 10.1016/j.cell.2015.04.026.

  3. 52.Gao B., Chen R., Liu X., Dai J. and Sun F.* (2015), Expression, purification, crystallization and crystallographic study of the Aspergillus terreus acromatic prenyltransferase AtaPT. Acta Crystallogr F Struct Biol Commun. F71: 889-894. doi: 10.1107/S2053230X15008882.

  4. 53.Sun F. (Sun Fang), Pang X., Xie T., Zhai Y., Wang G.G.* and Sun F.*  (2015), BrkAutoDisplay: functional display of multiple exogenous proteins on the surface of Escherichia coli by using BrkA autotransporter. Microbial Cell Factories. 14: 129. doi: 10.1186/s12934-015-0316-3.

  5. 54.Liu B., Xue Y., Zhao W., Chen Y., Fan C., Gu L., Zhang Y., Sun L., Huang X., Ding W., Sun F., Ji W.* and Xu T.* (2015), Three-dimensional super-resolution protein localization correlated with vitrified cellular context. Sci Rep 5, 13017. doi: 10.1038/srep13017.

  6. 55.Han R., Wang L., Liu Z., Sun F.* and Zhang F.* (2015), A novel fully automatic scheme for fiducial marker-based alignment in electron tomography. Journal of Structural Biology 192: 403-17. doi: 10.1016/j.jsb.2015.09.022.  (The program markerauto can be downloaded from

Year 2014

  1. 56.Pang X., Fan J., Zhang Y., Zhang K., Gao B., Ma J., Li J., Deng Y., Zhou Q., Egelman E.H., Hsu V.W.* and Sun F.* (2014), A PH Domain in ACAP1 Possesses Key Features of the BAR Domain in Promoting Membrane Curvature. Developmental Cell, 31(1) : 73-86. doi: 10.1016/j.devcel.2014.08.020. [CAS News] This paper was commented and previewed in the same issue by Haucke and  colleagues (Dev. Cell. 31(1) : 3-4.). [This research has been recommended In F1000Prime, 17 Nov 2014; DOI: 10.3410/f.719709901.793501476.]

  1. 57.Xu Y., Li H., Jin YH., Fan J.* and Sun F.* (2014), Dimerization interface of 3-hydroxyacyl-CoA dehydrogenase tunes the formation of its catalytic intermediate. PLOS one. 9(4): e95965. doi:10.1371/journal.pone.0095965.

  2. 58.Ma J. and Sun F.* (2014), Expression, purification, crystallization and preliminary crystallographic study of the cytoplasmic domain of the mitochondrial dynamics protein MiD51. Acta Crystallographica Section F. F70: 596-599. doi:10.1107/S2053230X14006827.

  3. 59.Sun F., Li J. and Chen C.* (2014), Puzzle out the regulation mechanism of PI4KIIα activity. Sci China Life Sci. doi: 10.1007/s11427-014-4656-8.

  4. 60.Zhou Q., Li J., Yu H., Zhai Y., Gao Z., Liu Y., Pang X., Zhang L., Schulten K., Sun F.* and Chen C.* (2014), Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα. Nature Communications, 5:3552. doi:10.1038/ncomms4552. [CAS News] [This research has been recommended In F1000Prime, 18 Jul 2014; DOI: 10.3410/f.718326221.793497426.]

  1. 61.Qiu B., Zhang K., Wang S., Sun F.* (2014). C-terminal motif within Sec7 domain regulates guanine nucleotide exchange activity via tuning protein conformation. Biochem Biophys Res Commun, 446(1) : 380-386. doi: 10.1016/j.bbrc.2014.02.125.

  2. 62.Han R., Zhang F., Wan X., Fernandez J.J., Sun F. and Liu Z. (2014). A marker-free automatic alignment method based scale-invariant features. Journal of Structural Biology, 186 : 167-180. doi: 10.1016/j.jsb.2014.02.011.

  3. 63.Cheng, L., Huang, X., Li, X., Xiong, W., Sun, W., Yang, C., Zhang, K., Wang, Y., Liu, H., Huang, X., Ji, G., Sun F., Zheng, C.* and Zhu, P.* (2014). Cryo-EM structures of two bovine adenovirus type 3 intermediates. Virology, 450-451 :  174-181.

Year 2013

  1. 64.Zhang, Y., and Sun F.* (2013). Electron Microscopy Reconstruction of Helical Assemblies. Acta Biophys Sin, 29: 879-898.

  1. 65.Sun F.*, Zhou Q., Pang X., Xu Y. and Rao Z. (2013), Revealing various coupling of electron transfer and proton pumping in mitochondrial respiratory chain. Current Opinion in Structural Biology, 23: 526-538. doi: 10.1016/

  1. 66.Zhang K., Wang L., Liu Y., Chan K.Y., Pang X., Schulten K., Dong Z. and Sun F.* (2013), Flexible interweaved termini determine the thermal stability of thermosomes. Protein Cell, 4(6): 432-444. doi: 10.1007/s13238-013-3026-9.

  1. 67.Zhang Y., Wang W., Chen J., Zhang K., Gao F., Gao B., Zhang S., Dong M., Besenbacher F., Gong W., Zhang M., Sun F.* and Feng W.* (2013), Structural insights into the intrinsic self-assembly of Par-3 N-terminal domain. Structure, 21(6):997-1006. doi: 10.1016/j.str.2013.04.004.

  1. 68.Lu J., Zhai Y. and Sun F.* (2013), Research of Mitochondrial Calcium Transportation. ACTA BIOPHYSICA SINICA, 29(3): 167-180.

  2. 69.Xu Y. and Sun F.* (2013), Purification, crystallization and preliminary crystallographic analysis of 3-hydroxyacyl-CoA dehydrogenase from Caenorhabditis elegans. Acta Crystallographica Section F, F69: 515-519. doi:10.1107/S1744309113007045.

  3. 70.Wu L., Zhai Y., Lu J., Wang Q. and Sun F.* (2013), Expression, purification and preliminary characterization of glucagon receptor extracellular domain. Protein Expression and Purification, 89: 232-240. doi: 10.1016/j.pep.2013.04.004.

  4. 71.Quinlan R., Zhang Y., Lansbury A., Williamson I., Pohl E.* and Sun F.* (2013), Changes in the quaternary structure and function of MjHSP16.5 attributable to deletion of the I-X-I motif and introduction of the substitution, R107G in the alpha-crystallin domain. Philosophical Transactions of The Royal Society B, 368. doi:10.1098/rstb.2012.0327.

  1. 72.Wang X., Xu F., Liu J., Gao B., Liu Y., Zhai Y., Ma J., Zhang K., Baker T.S., Schulten K., Zheng D.*, Pang H.* and Sun F.* (2013), Atomic model of rabbit hemorrhagic disease virus by cryo-electron microscopy and crystallography. PLoS Pathogens, 9(1): e1003132. doi: 10.1371/journal.ppat.1003132. [NSFC News][China Science Daily News][NCSA of UIUC News]

  1. 73.Zhang S., Andreasen M., Nielsen J.T., Liu L., Nielsen E.H., Song J., Ji G., Sun F., Skrydstrup T., Besenbacher F., Nielsen N.C., Otzen D.E and Dong M.* (2013), Coexistence of ribbon and helical fibrils originating from hIAPP20-29 revealed by quantitative nanomechanical atomic force microscopy. PNAS, doi:10.1073/pnas.1209955110.

  2. 74.Wang L., Li Q., Wu L., Liu S., Zhang Y., Yang X., Zhu P., Zhang H., Zhang K., Lou J., Liu P., Tong L.*, Sun F.* and Fan Z.* (2013), Identification of SERPINB1 as a physiological inhibitor of human granzyme H. The Journal of Immunology, 190(3):1319-30. doi:10.4049/jimmunol.1202542.

  3. 75.Yang S., Liu X., Li, X., Sun S.F., Sun F., Fan B., and Zhao S.* (2013), MicroRNA-124 reduces caveolar density by targeting caveolin-1 in porcine kidney epithelial PK15 cells. Molecular and cellular biochemistry 384, 213-219.

  4. 76.Wang G., Zhang F., Fan L., Sun F. and Liu, Z. (2013) Contrast Transfer Function Correction Model Based on Sine and Gaussian Modulation and Spline Interpolation. Journal of Computer Research and Development 50, 808-814.

  5. 77.Wang G., Zhang F., Fan L., Sun F. and Liu, Z. (2013) A fast calculation strategy of density function in ISAF reconstruction algorithm. Scientia Sinica Informationis 43, 584-598.

Year 2012

  1. 78.Zhao Y., Zhao H., Miao L., Wang L., Sun F. and Zhang H. (2012), The p53-induced gene Ei24 is an essential component of the basal autophagy pathway. Journal of Biological Chemistry, 287(50):42053-63.

  2. 79.Wang S. and Sun F.* (2012), Dynactin is an indispensable helper for dynein’s function in intracellular motility. ACTA BIOPHYSICA SINICA, 28(10):785-793.

  3. 80.Bai M., Pang X., Lou J., Zhou Q., Zhang K., Ma J., Li J., Sun F.* Hsu V.* (2012), Mechanistic insights into regulated cargo binding by ACAP1.  Journal of Biological Chemistry, 287: 28675-28685.

  4. 81.Hu J., Sun L., Shen F., Chen Y., Hua Y., Liu Y., Zhang M., Hu Y., Wang Q., Xu W., Sun F., Ji J., Murray J., Carr A., Kong D.* (2012), The Intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing. Cell, 149: 1221-1232.

  5. 82.Yang C., Ji G., Liu H., Zhang K., Liu G., Sun F., Zhu P.*, Cheng L*. (2012), Cryo-EM structure of a transcribing cypovirus. PNAS, 109(16): 6118-6123.

  6. 83.Wang G., Zhang F., Sun F., Liu Z. (2012), An accelerated ISAF algorithm with the fast mapping strategy. Journal of Computers, 7(2): 528-533.

  7. 84.Guo H., Yuan X., Liu J., Shan G., Chi X., Sun F. (2012), Interference microscopy volume illustration for biomedical data. Pacific Visualization Symposium (PacificVis), 2012 IEEE. 177-184. doi: 10.1109/PacificVis.2012.6183589.

  8. 85.Wang L., Zhang K., Wu L., Liu S., Zhang H., Zhou Q., Tong L., Sun F.* and Fan Z.*. (2012), Structural Insights into the substrate specificity of human granzyme H - the functial roles of a novel RKR motif. The Journal of Immunology, 188(2): 765-73.

  9. 86.Wang X., Wang L., Wang Xi., Sun F.* and Wang C.C.*.(2012), Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4. Biochem. J.,441: 113-118.

Year 2011

  1. 87.Cheng L., Sun J., Zhang K., Mou Z., Huang X., Ji G., Sun F., Zhang J.*, Zhu P.* (2011), Atomic model of a cypovirus built from cryo-EM structure provides insight into the mechanism of mRNA capping. PNAS, 108(4):1373-1378.

  2. 88.Wang L., Zhang K., Fan Z., Dong Z., Sun F.* (2011), Substrate binding properties of thermosome ATcpn-beta from Acidianus Tengchongensis. Progress in Biochemistry and Biophysics, 38(2):151-158.

  3. 89.Zhai Y., Zhang K., Huo Y., Zhu Y., Zhou Q., Lu J., Black I., Pang X., Roszk A.W., Zhang X., Isaacs N.W., Sun F.* (2011), Autotransporter passenger domain secretion requires a hydrophobic cavity at the extracellular entrance of the beta-domain pore. Biochem. J. , 435:577-587. (This paper was featured as a key scientific article by Global Medial Discovery.))

  4. 90.Chu Q., Zhang K., Wan X., Zhang C., Zhang Y., Zhang G., Shen B., Lu X., Zhao K.,Chu X., Zhang F.*, Sun F.* (2011), ATOM1.0 : A GPU Powered Package for Electron Tomography Reconstruction. ACTA BIOPHYSICA SINICA, 27(3):231-241. (The software ATOM1.0 could be found here.)

  5. 91.Zheng X., Guo J., Xu L., Li H., Zhang D., Zhang K.,Sun F., Wen T., Liu S., Pang H.* (2011), Crystal Structure of a Novel Esterase Rv0045c from Mycobacterium tuberculosis. PLoS ONE, 6(5): e20506. doi:10.1371/journal.pone.0020506

  6. 92.Wan X., Zhang F., Chu Q., Zhang K., Sun F., Yuan B., Liu Z.* (2011), Three-dimensional reconstruction using an adaptive simultaneous algebraic reconstruction technique in electron tomography. Journal of Structural Biology , 175(3):277-87. doi:10.1016/j.jsb.2011.06.002

  7. 93.Zhou Q., Zhai Y., Lou J., Liu M., Pang X. and Sun F.* (2011), Thiabendazole inhibits ubiquinone reduction activity of mitochondrial respiratory complex II via a water molecule mediated binding feature. Protein & Cell, 2(7):531-542, doi:10.1007/s13238-011-1079-1 (cover story).


  1. 94.Li M., Xu G.*, Sorzano, O.S.C., Sun F. and Bajaj L.C. (2011), Single-particle reconstruction using L2-gradient flow. Journal of Structural Biology,176:259-267. doi:10.1016/j.jsb.2011.08.005.

  2. 95.Sun Fei* and Wang Xue. (2011), Application and aspect of cryo-electron microscopy for the structural study of membrane proteins. Chinese Bulletin of Life Sciences, 23(11):1130-1139.

  3. 96.Chen Shaohong, Pang Xiaoyun and Sun Fei*. (2011), Mitochondrial movement and its related cytoskeletons and proteins. ACTA BIOPHYSICA SINICA, 27(12):1019-1029.

  4. 97.Wang G., Zhang F., Fan L., Sun F., Liu Y. (2011), Analysis and solution of complexity of basis function in ISAF reconstruction algorithm. Journal of Computer-Aided Design & Computer Graphics. 23 (7) : 1148-1158.


Year 2010

  1. 98.Li Z., Zhai Y., Fang J., Zhou Q., Geng Y., Sun F.* (2010), Purification, crystallization and preliminary crystallographic analysis of very long chain Acyl-CoA dehydrogenase from Caenorhadbitis elegans. Acta Crystallographica Section F, F66: 426-430.

  2. 99.Wang L., Hu Z., Luo Y., Huo Y., Ma Q., He Y., Zhang Y., Sun F.*, Dong Z.* (2010), Distinct symmetry and limited peptide refolding activity of the thermosomes from the acidothermophilic archaea Acidianus tengchongensis S5T, Biochem Biophys Res Commun, 393: 228-234.

  3. 100.Li Z., Zhang K., Zhai Y., Zhou Q., Geng Y., Sun F.* (2010), Cloning, Expression, Purification and Preliminary Crystallographic Analysis of Caenorhabditis elegnas Enoyl-CoA Hydratase. Acta Biophysica Sinica, 26(1):37-48.

  4. 101.Hu Z., Tian X., Zhai Y., Xu W., Zheng D., Sun F.* (2010), Cryo-Electron Microscopy Reconstructions of Two Types of Wild Rabbit Hemorrhagic Disease Viruses Characterized the Structural Features of Lagovirus. Protein & Cell, 1(1):48-58. (Cover story)


  1. 102.Zhou Q., Sun J., Zhai Y., Sun F.* (2010). Prokaryotic Expression of Active Mitochondrial Uncoupling Protein 1. Progress in Biochemistry and Biophysics, 37(1): 56~62.

  2. 103.Li S., Zhao Q., Zhou Q., Unno H., Zhai Y., Sun F.*(2010). The Role and Structure of Carboxyl-terminal Domain of the Human Voltage-gated Proton Channel HV1. Journal of Biological Chemistry, 285 (16): 12047-12054.

  3. 104.Zhang S., Zhang K., Chen X., Chu X., Sun F.*, Dong Z. (2010), Five mutations in N-terminus confer thermostability on mesophilic xylanase, BBRC, 395: 200-206.

  4. 105.Lu B., Zhai Y., Wu C., Pang X., Xu Z. and Sun F.* (2010), Expression, purification and preliminary biochemical studies of the N-terminal domain of leucine-rich repeat kinase 2, Biochimica et Biophysica Acta, 1804: 1780-1784.

  5. 106.Zhang K., Zhang Y., Hu Z., Gang J. and Sun F.* (2010), Development and Frontier of Electron Microscopy 3D Reconstruction. ACTA BIOPHYSICA SINICA, 26(7): 533-559. (cover story)


  1. 107.Zhang Y, Liu D, Chen X, Li J, Li L, Bian Z, Sun F., Lu J, Yin Y, Cai X, Sun Q, Wang K, Ba Y, Wang Q, Wang D, Yang J, Liu P, Xu T, Yan Q, Zhang J, Zen K, Zhang CY. (2010). Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol. Cell, 39(1):133-44.

  2. 108.Hu YW, Hu ZJ, Zhang K, Wang L, Zhai Y, Zhou QJ, Lander G, Zhu J, He YZ, Pang XY, Xu W, Bartlam M, Dong ZY, Sun F.*. (2010). Crystal structure of group II chaperonin in the open state. Structure, 18(10): 1270-1279. (cover story)


  1. 109.Ma J, Sun F.* (2010). Translocation of Mitochondrial Proteins. ACTA BIOPHYSICA SINICA, 26(10): 880-893.

  2. 110.Xu L., Guo J., Zheng X., Wen T., Sun F., Liu, S., and Pang, H.* (2010). Crystallization and preliminary X-ray analysis of a novel esterase Rv0045c from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun 66, 1579-1582.


Year 2009

  1. 111.Zhang K,, Zhang C,, Sun F*. (2009) Disclosing the Structure and Function of Translation Machine - Introduction of the Noble Prize in Chemistry 2009. Acta Biophysica Sinica, 25(5):325-334.

  2. 112.Wu L., Wang L., Hua G., Liu K., Yang X., Zhai Y., Bartlam M., Sun F*. and Fan Z.* (2009) Structural Basis for Proteolytic Specificity of the Human Apoptosis-Inducing Granzyme M, The Journal of Immunology, 183, 421-9.

  3. 113.Sun S.,Zhang K., Xu W.,Wang G.,Chen J. and Sun F*. (2009) 3D Structural Investigation of Caveolae From Porcine Aorta Endothelial Cell by Electron Tomography, Progress in Biochemistry and Biophysis, 36(6), 729-35.

Year 2008

  1. 114.Sun, F.*#, Zhou, Q. J., Sun, J., Zhai, Y. J. & Rao, Z. H. (2008) Structure of mitochondrial respiratory membrane protein complexes, Chinese Bulletin of Life Sciences. 20.

  2. 115.Wang, L., Wang, L., Vavassori, S., Li, S., Ke, H., Anelli, T., Degano, M., Ronzoni, R., Sitia, R., Sun, F.* & Wang, C. C.* (2008) Crystal structure of human ERp44 shows a dynamic functional modulation by its carboxy-terminal tail, EMBO Rep. 9, 642-7.

  3. 116.Chen, J., Li, W., Wang, M., Zhu, G., Liu, D., Sun, F., Hao, N., Li, X., Rao, Z. & Zhang, X. C. (2008) Crystal structure and mutagenic analysis of GDOsp, a gentisate 1,2-dioxygenase from Silicibacter pomeroyi, Protein Sci. 17, 1362-73.

Year 2007

  1. 117.Huo X, Su D, Wang A, Zhai Y, Xu J, Li X, Bartlam M, Sun F*, Rao Z. 2007. Preliminary molecular characterization and crystallization of mitochondrial respiratory complex II from porcine heart , FEBS JOURNAL, 274(6): 1524-1529

  2. 118.Zheng, W., Sun, F., Bartlam, M., Li, X., Li, R. & Rao, Z. (2007) The crystal structure of human isopentenyl diphosphate isomerase at 1.7 a resolution reveals its catalytic mechanism in isoprenoid biosynthesis, J Mol Biol. 366, 1447-58.

Year 2002-2006

  1. 119.Su D, Lou Z, Sun F, Zhai Y, Yang H, Zhang R, Joachimiak A, Zhang XC, Bartlam M, Rao Z. 2006. Dodecamer Structure of Severe Acute Respiratory Syndrome Coronavirus Nonstructural Protein nsp10. J Virol. 80(16):7902-8.

  2. 120.Xu X, Zhai Y, Sun F, Lou Z, Su D, Xu Y, Zhang R, Joachimiak A, Zhang XC, Bartlam M, Rao Z. 2006. New Antiviral Target Revealed by the Hexameric Structure of Mouse Hepatitis Virus Nonstructural Protein nsp15. J Virol. 80(16):7909-17.

  3. 121.Li X, Liu X, Sun F, Gao J, Zhou H, Gao GF, Bartlam M, Rao Z. 2006. Crystal structure of the N-terminal SH3 domain of mouse betaPIX, p21-activated kinase-interacting exchange factor. Biochem Biophys Res Commun. 339(1):407-14.

  4. 122.孙飞#,徐建兴,饶子和.2005.膜蛋白三维结构研究的新突破-线粒体呼吸链膜蛋白复合物II结构解析.中国科学院院刊. 2005(5):381-384

  5. 123.Zhai Y#, Sun F#, Li X, Pang H, Xu X, Bartlam M & Rao Z. 2005. Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamer. Nat. Struct. Mol. Biol. 12(11): 980-986

  6. 124.Sun F#, Huo X, Zhai Y, Wang A, Xu J, Su D, Bartlam M& Rao Z. 2005. Crystal structure of mitochondrial respiratory membrane protein complex II. Cell, 121: 1043-1057.

  7. 125.Shi N, Ye S, Bartlam M, Yang M, Wu J, Liu Y, Sun F, Han X, Peng X, Qiang B, Yuan J & Rao Z. 2004. Structural Basis for the Specific Recognition of RET by the Dok1 Phosphotyrosine Binding Domain. J Biol Chem., 279(6): 4962-9

  8. 126.Shi N, Ni M, Yang M, Wu J, Peng Y, Gao F, Sun F, Peng X, Qiang B, Rao Z & Yuan J. 2004. Expression, crystallization and preliminary X-ray studies of the recombinant PTB domain of mouse dok-1 protein. Acta Cryst., D60(2): 334-336

  9. 127.Sun F#, Li P, Ding Y, Wang L, M Bartlam, Shu C, Shen B, Jiang H, Li S & Rao Z. 2003. Desian and Structure Based Study of New Potential FKBP12 Inhibitors. Biophysical Journal, 85 (5): 3194-3201.  

  10. 128.Ding Y, Li S, Li XF, Sun F, Liu JY, Zhao NM & Rao Z. 2003. Site-directed Mutagenesis and Preliminary X-ray Crystallographic Studies of the Tabtoxin Resistance Protein. Protein and Peptide Letters, 10(3): 255-263

  11. 129.Lin W, Sun F & Rao Z 2003. A Statistical Analysis of Protein-Protein Interaction with Knowledge-Based Potential at Residue Level. Tsinghua Science and Technology, 8(4): 402-406

  12. 130.Li T, Sun F, Ji X, Feng Y & Rao Z. 2003. Structure Based Hyperthermostability of Archaeal Histone HPhA from Pyrococcus horikoshii. J Mol Biol., 325: 1031-1037

  13. 131.He H, Ding Y, Bartlam M, Sun F, Le Y, Qin X, Tang H, Zhang R, Joachimiak A, Liu J, Zhao N&Rao Z. 2003. Crystal Structure of Tabtoxin Resistance Protein Complexed with Acetyl Coenzyme A Reveals the Mechanism for β­Lactam Acetylation. J Mol Biol., 325(5): 1019-1030

  14. 132.Li T, Ji X, Sun F, Gao R, Cao S, Feng Y & Rao Z. 2002. Crystallization and preliminary X-ray analysis of recombinant histone HphA from the hyperthermophilic archaeon Pyrococcus horikoshii OT3. Acta Cryst. D58: 870-871

  15. 133.Lin W, Sun F* & Rao Z. 2002. Tri-residue contact potential: a new knowledge-based energetic method. Progress in Natural Science, 12(11): 826-840



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